The Charles V Castle in Monopoli is a 16th-century fortress built during Spanish domination, now an important cultural venue in the city.

The sacred area (temple) of Vastogirardi is a Samnite sanctuary, in the locality of S. Angelo, is located about a kilometer from Vastogirardi, in the heart of Sannio pentro. The temple was built between 130-120 BC and still used in the imperial age. Among the many materials found there are a statuette of an ox, a clay plaque depicting a nose and two eyes and numerous unguentariums in glass and terracotta that have led to speculate the existence of healing rites related to the water of the nearby spring, still called "the water of the angels".