Palazzo Granafei-Nervegna is an elegant 16th-century palace. It is a valuable cultural venue that houses the original capital of one of two Roman columns in the city.

The center of Piazza Celestino V is dominated by the majestic Fontana Fraterna, an imposing artwork from the 18th century that enchants the eyes of anyone who admires it. The fountain rapresents a symbol of unity and community, and it has become an icon of Isernia throughout the centuries.