The Sanctuary of the Madonna di Bisaccia is about 1 km from the centre of Montenero di Bisaccia, situated on a hill and close to the Tratturo Centurelle - Montesecco, a derivation of the Reale Tratturo L'Aquila - Foggia. It dates back to 1200, and besides being a place of worship to which the inhabitants of Montenero are most attached, it is also the destination of many pilgrimages coming not only from Molise but also from Abruzzo and Puglia. The Sanctuary of the Madonna di Bisaccia was built on the ruins of an earlier chapel destroyed by various earthquakes. Originally, the central plan dates back to 1811, while the side aisles were added in 1840.

The Roman columns are the symbol of the city of Brindisi. Built in the 2nd century AD, they ideally celebrated the culmination of the most important roads of the time, the Via Appia and the Via Traiana (Appian Way and the Trajan Way).