The Castle of Manfredonia is the imposing building that houses the town's National Archaeological Museum. The Castle and the Museum together tell the very ancient history of the Siponto and Gargano areas.

The Matese Massif is a mountainous complex of karstic origin, here the water over the millennia has carved a system of caves of incredible beauty that from the speleological point of view represents one of the most important hypogeal sites of the southern Apennines. The abyss Pozzo della Neve is located in the beechwood of Costa del Carpine, in the locality of Tornieri, inside the WWF Oasis of Guardiaregia-Campochiaro. The site, of considerable interest and high environmental value, is located within the protected area SIC-ZPS largest region of Molise.